Endocrine Abstracts

Decamethylcyclopentasiloxane (D5) is one of the most common chemical ingredients for daily necessities that can be absorbed through the skin, aerosol, or even orally. People are exposed to D5 daily, but the risk of prenatal exposure to D5 is not completely understood. In this study, the effects of prenatal exposure to D5 on neural development were assessed through behavioral tests on offspring mice. First, the developmental neurotoxicity test (DNT) was performed to determine i...

Potassium-dependent sodium/calcium exchanger (NCKX3) is expressed in the brain, smooth muscle, the uterus, and intestine. NCKX3 gene plays a role in transporting intracellular calcium and potassium ions across the cell membrane in exchange for extracellular sodium ions. This gene is also associated with calcium metabolism in bones. Tight junctions have functional barriers for material transport and osmotic balance, which are regulated by calcium metabolism. Claudin, o...

Decamethylcyclopentasiloxane(D5) is one of the most common chemical ingredient for cosmetic products, cleansing agents, hairdye, dry cleaning solvent and personal hygiene supplies. D5 is also known as estrogenic chemical. It can be absorbed through skin, airosol, and even oraly. People are exposed to D5 in daily environment. However, the risk of prenatal exposure to D5 has not yet been fully understood. Recent research shows that imbalance of dam’s estrogen induces brain ...

Mitochondria play a key role in hormone biosynthesis and involve in renal cell proliferation by producing about 90% of cellular energy and controlling cell apoptosis. Doxorubicin is commonly used for many tumor treatments. However, its clinical utility is limited by the adverse reactions, which are known to be nephrotoxic. The mechanism by which doxorubicin induced kidney damage is still not completely understood, however nephrotoxicity by doxorubicin might be related to mitoc...

Calcium signaling plays a regulatory role in the events of cellular proliferation. In immunocytes such as T cells, B cells, mast cells and many other cell types, Ca2+ signals show to control the proliferation, differentiation, and function. Furthermore, Ca2+ has been shown to act as a second messenger to regulate innate immune cell function and activation. Here, we found that loss of Nckx3, a potassium-dependent Na+ /Ca2+</...

Perinatal action of estrogens or aromatizable steroids at the central nervous system level is responsible for brain development. 4-tert-octylphenol (OP) is knows as an endocrine disrupting chemical (EDC) that is widespread estrogenic chemical used in the costumer produces. Thus, we hypothesis that through early contact with the central nervous system, OP could alter the processes affecting behavior. In this study, primary cortical neurons were exposure to OP (10–6</...

Ca2+ homeostasis has been reported to play important roles in various cell systems. In central nerves system, the dysregulation of Ca2+ homeostasis can induce the excitotoxic and neurodegeneration. NCKX3 (Sodium/potassium/calcium exchanger 3), a novel member of the family of K+-dependent Na+/Ca2+ exchangers, is an important component of intracellular Ca2+ homeostasis. In addition, NCKX3 highly expressed in tha...